MCM5 Proteins are excellent cancer biomarkers because:
They are robustly expressed in dividing cells and those preparing to divide
MCM proteins are not expressed in fully differentiated cells
When a mass of replicating cells, such as a bladder tumour, is present MCM positive cells are shed into the body fluids
MCM positive cells are not usually present in body fluids in the absence of cancer or epithelial damage
The MCM technology is applicable to a number of cancer types and there is a well-defined requirement for screening tests in number of cancer types for which the MCM technology could offer a clinically relevant test.
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