There are 150,000 bladder cancer diagnoses in EU per year
Ferlay J et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer 49(6), 1374-1403 (2013).
Bladder cancer has a 65% recurrence rate, the highest of any malignancy
National Cancer Institute’s SEER database
The gold-standard diagnostic test for bladder cancer, cystoscopy, is invasive, uncomfortable and expensive
5 million haematuria patients undergo cystoscopy in Europe each year
Ferlay J et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer 49(6), 1374-1403 (2013)
Only 10% of haematuria patients are typically diagnosed with bladder cancer
Edwards TJ, Dickinson AJ, Natale S, et al. A prospective analysis of the diagnostic yield resulting from the attendance of 4020 patients at a protocol-driven haematuria clinic. BJU Intl 2006; 97(2): 301–5
White Light Cystoscopy is considered the gold standard test for bladder cancer
Deshpande A et al. Bladder cancer diagnosis and management. GM, 06, 2014.
Up to 30% of bladder cancers are missed at initial cystoscopy
Jocham D et al. Photodynamic diagnosis in urology: state-of-the-art. Eur Urol 53(6): 1138-48 (2008)
Zhangqun Ye et al. A comparison of NBI and WLI cystoscopy in detecting non-muscle-invasive bladder cancer: A prospective, randomized and multi-center study. Sci Rep.; 5:10905 (2015).
Cells containing MCM proteins are found in body fluids when a cancer is present because the cells are shed by tumours
Where the MCM protein is found it is an signpost for the most likely form of cancer. MCM in the…
Urine is indicative of bladder cancer
Semen could be indicative of prostate cancer
MCM positive cells are not usually present in body fluids in the absence of cancer or epithelial damage
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